Cdc42-dependent formation of the ZO-1/MRCKb complex at the leading edge controls cell migration
نویسندگان
چکیده
Lin Huo, Wenyu Wen, Rui Wang, Chuen Kam, Jun Xia, Wei Feng* and Mingjie Zhang* Division of Life Science, Molecular Neuroscience Center, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, Department of Chemistry, Shanghai, China, Institutes of Biomedical Sciences, Fudan University, Shanghai, China and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
منابع مشابه
Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration.
Zonula occludens (ZO)-1 is a multi-domain scaffold protein known to have critical roles in the establishment of cell-cell adhesions and the maintenance of stable tissue structures through the targeting, anchoring, and clustering of transmembrane adhesion molecules and cytoskeletal proteins. Here, we report that ZO-1 directly binds to MRCKβ, a Cdc42 effector kinase that modulates cell protrusion...
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تاریخ انتشار 2011